Thomas Perlmann’s group is interested in how specific cell types of the central nervous system are generated and how they are maintained. The group is mostly focusing on neurons using dopamine as its neurotransmittor and is unraveling the signaling and transcriptional regulation that govern the specification, differentiation and maintenance of these cells. The studies have resulted in the identification of several transcription factors with key roles in these processes. The projects are focused on understanding functions in both early specification events and in maintenance of dopamine neurons in the adult brain. Moreover, we are also interested in regenerative medicine in relation to Parkinson’s disease and other brain disorders.

Group members

Thomas Perlmann

Thomas Perlmann

Group leader

Thomas obtained his PhD in 1991 at the Karolinska Institutet. He was a postdoctoral fellow at the Salk Institute for Biological Studies in San Diego from 1991-1994. He became a professor at the Karolinska Institutet in 2001. In addition to the group leader position he is also the Secretary General of the Nobel Assembly and Nobel Committee at the Karolinska Institutet.

Katarina Tiklova

Katarina Tiklova

Postdoctoral Researcher

Katarina received a Master's degree in molecular biology at the Faculty of Natural Sciences, Comenius University, in Slovakia. Her PhD studies with Prof. Christos Samakovlis at the Stockholm University focused on airway maturation in Drosophila.

Laura Lahti

Laura Lahti

Postdoctoral Researcher

Laura obtained her PhD in genetics in 2012 at the University Helsinki, Finland, where she studied regulation of embryonic neurogenesis and specification of neural subtypes in the midbrain and hindbrain region.

Linda Gillberg

Linda Gillberg

Research Engineer

Linda received her MSc in Biomedicine and her PhD in Medical Science from Karolinska Institutet. Her doctoral studies with Prof. Per Hellström focused on inflammatory markers in the gastrointestinal tract.