Our group is interested in how specific cell types of the central nervous system are generated and how they are maintained. We are mostly focusing on neurons using dopamine as neurotransmitter and we are unraveling the signaling and transcriptional regulation that govern the specification, differentiation and maintenance of these cells. The studies have resulted in the identification of several transcription factors with key roles in these processes. The projects are focused on understanding functions in both early specification events and in maintenance of dopamine neurons in the adult brain. Moreover, we are also interested in regenerative medicine in relation to Parkinson’s disease and other brain disorders.

Resources

Group members

Thomas Perlmann

Thomas Perlmann

Group leader

Professor in Molecular Developmental Biology

Nikolaos Volakakis

Nikolaos Volakakis

Senior Research Associate

Nick received his BSc in Biology from the Aristoteles University in Greece and his PhD in Medical Science from Karolinska Institute in Sweden. His doctoral studies focused on the structure and neuroprotective functions of the transcription factor Nurr1.

Katarina Tiklova

Katarina Tiklova

Postdoctoral Researcher

Katarina received a Master's degree in molecular biology at the Faculty of Natural Sciences, Comenius University, in Slovakia. Her PhD studies with Prof. Christos Samakovlis at the Stockholm University focused on airway maturation in Drosophila.

Laura Lahti

Laura Lahti

Postdoctoral Researcher

Laura obtained her PhD in genetics in 2012 at the University Helsinki, Finland, where she studied regulation of embryonic neurogenesis and specification of neural subtypes in the midbrain and hindbrain region.

Linda Gillberg

Linda Gillberg

Research Engineer

Linda received her MSc in Biomedicine and her PhD in Medical Science from Karolinska Institutet. Her doctoral studies with Prof. Per Hellström focused on inflammatory markers in the gastrointestinal tract.

Get in Touch

We are located at the Karolinska Institutet, Solna Campus, Stockholm, Sweden.

Visiting address

Nobels Väg 3, 17165 Solna, Sweden

Mailing address

Thomas Perlmann

Department of Cell and Molecular Biology, Karolinska Institutet

17177 Stockholm, Sweden

Send e-mail to a group member

firstname.lastname@ki.se